Normal cell proliferation is under the intrinsic control of growth- promoting proto- oncogenes and growth- constraining anti- oncogenes. Specifically, we are defining multifaceted roles of tumor associated antigens (MUC4 and PD2/h. Paf. 1) in the pathogenesis of pancreatic, breast, ovarian and prostate cancers. Similar Members DF/HCC members that share similar concepts* with Peter J. Park, PhD but have yet to coauthor a publication with this researcher. To apply for this degree program, an undergrad business degrees is not required (all undergraduate majors welcome). Obtaining certifications in specific areas of IT can enhance career prospects. 2013: MD Anderson Cancer Center, Team Science Award: 2012: MD Anderson Cancer Center, Faculty Scholar Award: 2012: MD Anderson Women Faculty Programs, 'Woman Leading the Way' 2012: National Institute of Health R01 Award: 2011. Notes about this list of Dubai MBAs. To add an MBA in Dubai to this list, start a new topic in the Dubai MBA forum. MBA finder includes Dubai MBA institutes and schools which offer UAE, UK, US, Australian, Canadian, Indian. Faculty profile of Sunil D Lakdawala, Visiting Faculty at SP Jain School of Global Management. Education: Harvard Medical School, 1998, MD, PhD California Institute of Technology, 1989, BS with honors : Link to PubMed: View Clark's Publications in PubMed. Publications (Pulled from Harvard Catalyst Profiles): 1. 2014 (MD-PhD student bolded/italics) Chivukula RR, Shi G, Acharya A, Mills EW, Zeitels LR, Anandam JL, Abdelnaby AA, Balch GC, Mansour JC, Yopp AC, Maitra A, Mendell JT. See available courses at S.P. Jain Institute of Management and Research (SPJIMR), find out about fees, admissions, courses, placement, faculty and much more only at Shiksha.com. We cloned the full- length MUC4 c. DNA (2. 8 Kb) from human pancreatic tumor c. DNA libraries and established its complete genomic organization (2. Figure 1). Our studies have demonstrated the specific and differential expression of MUC4 in many cancers compared to normal tissues. Furthermore, using a MUC4- specific MAb generated in our laboratory, we showed that de novo expression of MUC4 is observed in precancerous pancreatic intraepithelial neoplasias (Pan. INs) and its expression increases progressively with the development of PC. These results were further confirmed in collaboration with investigators at University of California at San Francisco and University of Alabama. Notably, the overexpression of MUC4 is also associated with a poor prognosis for patients with PC. In multiple in- vitro and in- vivo studies, we have shown that the aberrant expression of MUC4 in PC results from diverse regulatory mechanisms. MUC4 is a large- sized membrane- anchored glycoprotein. The size of the MUC4 apomucin is 9. Da and it is comprised of a 8. Da mucin- type subunit (MUC4. Several allelic and splice- variants of MUC4 are also reported. MUC4a possesses three important domains . In our recent studies, using . How is SP jain's Global Bachelor of Business Administration (BBA) Program? MUC4 was significantly associated with motility/invasion and anti- adhesive properties of pancreatic tumor cells. Interestingly, our study also revealed a correlative decrease in HER2 expression upon downregulation of MUC4. We have observed that both MUC4 and HER2 co- localize with each other at the cell surface and in the cytoplasm of PC cells. The physical association between MUC4 and HER2 was confirmed by coimmunoprecipitation and in vivo co- clustering. Our subsequent studies have indicated that MUC4- mediated regulation of HER2 may occur by post- transcriptional mechanism(s). In other studies, we have observed that MUC4 expression in NIH3. T3 mouse fibroblast cells leads to the oncogenic transformation of these cells. Taken together, the structural attributes of MUC4, its aberrant expression and functional role in the tumorigenicity and metastasis of cancer cells provide experimental evidence for the multifaceted roles of MUC4 in the progression cancer. Under normal conditions, MUC4 is localized at the apical surface of the epithelial cells. However, during the course of cancer progression, tumor cells lose polarity, allowing ubiquitous cell surface expression of MUC4 and its subsequent interaction with novel partner(s) such as HER2. Association of MUC4 with HER2 may protect disseminated tumor cell from anoikis via HER2- mediated mechanisms, thus facilitating the primary tumor growth. Overexpression of MUC4 on the cell surface further disrupts the interaction between adhesion molecules which may facilitate the motility and invasion properties of tumor cells. The process of metastasis may be further assisted by adhesion of MUC4 on endothelial cells by interacting with glycoproteins (Galectin- 3 or selectins). Currently, we are working on: Defining the mechanism(s) responsible for MUC4- mediated regulation of HER2 in pancreatic cancer cells. Determining the molecular mechanisms by which MUC4 contributes to tumor growth and metastasis. Investigating the co- operative action of MUC4 in combination with other defined oncogenic mutations, in the early development of pancreatic cancer. In addition to these goals, MUC4 is being explored as a maker for early diagnosis and target for active and passive therapy in many cancers in our laboratory. In addition to MUC4, other projects are: Genetically engineered multivalent single chain antibody constructs for cancer therapy. This proposal is aimed to generate, characterize, increase production and affinity of multivalent antibody constructs reactive with the tumor associated Sialyl- Tn antigen present on TAG- 7. The phage display technology is being used for the development of new tumor- specific human monoclonal antibodies. Understanding the dysregulation of PD2/h. Paf 1 and h. PAF1 complex in cancers. Molecular and biochemical studies on PDF/MIC- 1. Publications: Total 3. Publications (selected shown below from last three years): Costa- Silva B, Aiello NM, Singh S, Zhang H, Thakur BK, Becker A, Hoshino A, Mark MT, Molina H, Xiang J, Zhang T, Theilen T- M, Garc. Ocean AJ, Hernandez J, Doussot A, Ebbesen S, Grandgenett P, Hollingsworth MA, Jain M, Mallya K, Batra SK. Jarnagin WR, Schwartz RE, Matei I, Peinado H, Stanger B, Bromberg J, and Lyden DV (2. Pancreatic cancer exosomes initiate pre- metastatic niche formation in the liver. Nature Cell Biology 2. Jun; 1. 7(6): 8. 16- 2. PMID: 2. 59. 85. 39. Chari ST, Kelly K, Hollingsworth MA, Thayer SP, Ahlquist DA, Andersen DK, Batra SK, Brentnall TA, Canto M, Cleeter D, Firpo MA, Gambhir SS, Go VL, Hines OJ, Kenner BJ, Klimstra DS, Lerch MM, Levy MJ, Maitra A, Mulvihill SJ, Petersen GM, Rhim AD, Simeone DM, Srivastava S, Tanaka M, Vinik AI, Wong D. Early Detection of Sporadic Pancreatic Cancer: Summative Review. Pancreas, 2. 01. 5 Apr 2. PMID: 2. 59. 31. 25. Higashi, M, Yokoyama, S, Yamamoto, T, Goto Y, Hiraki T, Hashimoto S, Fukukura Y, Koriyama C, Shinchi H, Jain M, Batra S. K., and Yonezawa S. Mucin expression in EUS- FNA specimens is a useful prognostic factor in pancreatic ductal adenocarcinoma. Pancreas, in press, on line, 2. Apr 2. PMID 2. 59. Joshi S, Kumar S, Bafna S, Rachagani S, Wagner KU, Jain M, and Batra SK. Genetically engineered mucin mouse models for inflammation and cancer. Cancer Metastasis Review, 4. PMID 2. 56. 34. 25. Kumar S, Torres M, Kaur S, Rachagani S, Momi N, Baine M, Joshi S, Gilling C, Wyatt T, Jain, M, Joshi S and Batra SK. Smoking accelerates pancreatic cancer progression by promoting differentiation of MDSCs and inducing HB- EGF expression in macrophages. Oncogene 3. 4(1. 6): 2. PMID2. 49. 09. 16. Kamikawa Y, Kanmura Y, Hamada T, Yamada N, Macha MA, Batra SK, Higashi M, Yonezawa S, Sugihara K. Co- expression of MUC1 and MUC4 is associated with poor prognosis in oral squamous cell carcinoma patients. J of Clinical Oncol, 2. PMID: 2. 49. 09. 61. Yan, Y, Hein, A., Greer, P. M., Batra, S. K., Wang, Z., Kolb, R. H. A novel function of HER2/Neu in the activation of G2/M checkpoint in response to g- irradiation. Oncogene, 3. 4(1. PMID 2. 49. 09. 17. Jain S, Sukhlabaidya S, Das B, Raghav SK, Batra SK, and Senapati, S. TLR4. LR activation by lipopolysaccharide confers survival advantage to growth factor deprived prostate cancer cells. Prostate, 7. 5(1. PMID 2. 58. 33. 06. Kumar V, Mondal G, Slavik P, Rachagani S, Batra SK, and Mahato RI. Co- delivery of Small Molecule Hedgehog Inhibitor and mi. RNA for treating Pancreatic Cancer. Molecular Pharmaceutics, 1. PMID 2. 56. 79. 32. Das S, Rachagani S, Torres- Gonzalez MP, Lakshmanan I, Majhi PD, Smith LM, Wagner KU, Batra SK. Carboxyl- terminal domain of MUC1. JAK2 to pancreatic cancer cells. Oncotarget, 6(8): 5. PMID 2. 56. 91. 06. Macha MA, Krishn SR, Jahan R, Banerjee K, Batra SK, Jain M. Emerging potential of natural products for targeting mucins for therapy against inflammation and cancer. Cancer Treat Rev. PMID 2. 56. 24. 11. Seshacharyulu P, Ponnusamy MP, Rachagani S, Lakshmanan I, Haridas D, Yan Y, Ganti AK and Batra SK. Targeting EGF- receptor(s)–STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer. Oncotarget, 6(7): 5. PMID 2. 56. 86. 82. Macha M, Rachagani S, Pai P, Gupta S, Lydiatt W, Smith R, Johansson S, Lele S, Kakar S, Lee J, Meza J, Ganti. A, Jain. M and Batra SK. MUC4 Regulates Cellular Senescence in Head and Neck Squamous Cell Carcinoma (HNSCC) through p. Rb Pathway. Oncogene, 3. PMID 2. 47. 47. 96. Mimeault M, Rachagani S, Muniyan S, Seshacharyulu P, Johansson SL, Datta K, Lin MF and Batra SK. Inhibition of Hedgehog Signaling Improves the Anti- carcinogenic Effects of Docetaxel in Prostate Cancer. Oncotarget, 6(6): 3. PMID 2. 56. 82. 87. Pandey P, Rachagani S, Das S, Seshacharyulu P, Sheinin Y, Naslavsky N, Pan Z, Smith BL, Peters HL, Radhakrishnan P, Mc. Kenna NR, Giridharan SS, Haridas D, Kaur S, Hollingsworth MA, Mac. Donald RG, Meza JL, Caplan S, Batra SK, Solheim JC. Amyloid precursor- like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis. Oncotarget, 1. 0; 6(4): 2. PMID 2. 55. 76. 91. Lakshmanan I, Ponnusamy MP, Macha MA, Haridas D, Majhi PD, Jain M, Batra SK and Ganti AK. Mucins in lung Cancer: Diagnostic, Prognostic and Therapeutic Implications. Journal of Thoracic Oncology, 1. PMID 2. 53. 19. 18. Das S, and Batra SK. Pancreatic Cancer Metastasis: Are we being Pre- EMTed? Curr Pharm Des., 2. PMID 2. 55. 06. 89. Rachagani S, Macha MA, Heimann N, Seshacharyulu P, Haridas D, Chugh S, Batra SK. Clinical implications of mi. RNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer. Adv Drug Deliv Rev., 8. C: 1. 6- 3. 3, 2. PMID 2. 54. 53. 26. Krasnoslobodtsev AV, Torres MP, Kaur S, Vlassiouk IV, Lipert RJ, Jain M, Batra SK*, and Lyubchenko YL*. Nano- immunoassay with improved performance for detection of cancer biomarkers. Nanomedicine. NCOA3- mediated upregulation of mucin expression via transcriptional and post- translational changes during the development of pancreatic cancer. Ph. D Programme - Job Market. Hajo Adam (Germany, OB)Assistant Professor, Jesse H. Jones Graduate School of Business, Rice University (2. Visiting Assistant Professor and Postdoctoral Fellow of Management and Organisations, Kellogg School of Management, Northwestern University (2. Anupam Agrawal (India, TOM)Assistant Professor of Business Administration, College of Business, University of Illinois at Urbana Champaign (2. Karja Aral (Turkey, TOM)Assistant Professor of Operations Management, Whitman School of Management, Syracuse University (2. Atalay Atasu (Turkey, TOM)Associate Professor of Operations Management, Scheller College of Business, Georgia Institute of Technology (2. Assistant Professor of Operations Management, Scheller College of Business, Georgia Institute of Technology (2. Julie Battilana (France, OB)Associate Professor (2. Assistant Professor (2. Business Administration, Organisational Behaviour unit, Harvard Business School, Harvard University. Elena Belavina (Russia, TOM)Jane and Basil Vasilou Scholar (2. Neuber Family Faculty Fellow (2. Assistant Professor of Operations Management (2. Booth School of Business, University of Chicago. Neil Brisley (Great Britain/France, FIN)Associate Professor of Finance and Approved Doctoral Dissertation Supervisor, School of Accounting and Finance, University of Waterloo (2. Assistant Professor of Finance, Richard Ivey School of Business, University of Western Ontario (2. Inyoung Chae (Korea, MKT)Assistant Professor of Marketing, Goizueta Business School, Emory University (2. Tian Heng Chan (Malaysia, TOM)Assistant Professor of Operations Management, Goizueta Business School, Emory University (2. Wan Ting 'Kitty' Chiu (Hong. Kong/STR)Visiting Assistant Professor, Krannert School of Management, Purdue University (2. James A Christiansen (United States/France, STR)Senior Strategist, Institute for Environmental Entrepreneurship (2. Innovation Specialist, Mc. Kinsey and Company, Chicago Office (2. Director Renaissance Solutions Worldwide (1. Charles Corbett (Great Britain/The Netherlands, POM)Professor of Operations Management and Environment Management, Andersen School of Management, UCLA; Department Chair and Deputy Dean for Academic Affairs (2. Associate Professor and Dean of the MBA programme (2. Assistant Professor of Operations Management (1. Andersen School of Management, UCLA. Yann Cornil (France, MKT)Assistant Professor (Marketing and Behavioural Science Division), University of British Columbia, Sauder Business School (2. Nishant Dass (India, FIN)Associate Professor (with tenure; 2. Assistant Professor (2. Finance, Scheller College of Business, Georgia Institute of Technology. Alice J. De Koning (The Netherlands/Canada, STR)Associate Professor of Strategy and Entrepreneurship, Bertolon School of Business, Salem State University (2. Assistant Professor of Entrepreneurship, J. Mack Robinson College of Business, Georgia State University (2. Assistant Professor of Entrepreneurship, Centre for Entrepreneurship and Business Creation, Stockholm School of Economics (2. Faculty Member and Acting Director, Stockholm School of Entrepreneurship (1. Affiliate researcher, PEG Program, Jonkoping International Business School (1. Senior Research Associate, Centre for Advanced Studies in Leadership, Stockholm School of Economics (1. Laurens Debo (Belgium, POM)Associate Professor of Operations Management, Booth School of Business, University of Chicago (2. Assistant Professor of Operations Management, Booth School of Business, University of Chicago (2. Assistant Professor of Operations Management and Manufacturing, Tepper School of Business, Carnegie Mellon University (2. David Drake (United States, TOM)Assistant Professor of Business Administration, Harvard Business School, Harvard University (2. Geraldo L. Ferrer (Brazil, POM)Associate Professor of Operations Management, Graduate School of Business and Public Policy, Naval Postgraduate School (2. Chair, Operations and Logistics Management Area, Graduate School of Business and Public Policy, Naval Postgraduate School (2. Assistant Professor of Operations Management, Kenan- Flager Business School, University of North Carolina (1. Sergio Gaspar (Portugal FIN)Associate, Cornerstone Research, Silicon Valley (2. Aline Gatignon (French/USA, STR)Assistant Professor of Management, The Wharton School, University of Pennsylvania (2. Jim Goldman (Belgium, FIN)Assistant Professor of Finance, University of Toronto (2. Dana G. Hyde (Canada, STR)Director - Bachelor of Commerce Programme/Directrice Programme de baccalaureat en sciences commerciales, Telfer School of Management, University of Ottawa (2. Assistant Professor, Strategy and General Management, Telfer School of Management, University of Ottawa (2. Faculty Member - Executive MBA Program, Telfer School of Management, University of Ottawa (2. Visiting Assistant Professor - Vlerick Business School (2. Assistant Professor - Babson College (1. Rajkamal J. Iyer (India, FIN)Associate Professor of Finance (2. Assistant Professor of Finance (2. Sloan School of Management, MIT; Assistant Professor of Finance, Faculty of Economics and Business Administration, University of Amsterdam (2. Rupinder P. Jindal (India, MKT)Assistant Professor of Marketing, Milgard School of Business, University of Washington Tacoma (2. Assistant Professor of Marketing, C. T. Bauer College of Business, University of Houston (2. Chaitanya 'CK' Kaligotla (India, DSC)Post Doctoral Appointee, Argonne National Laboratory (2. Rahul Kapoor (Singapore, STR)Associate Professor of Management (2. Assistant Professor of Management (2. The Wharton School, University of Pennsylvania. Zsolt Katona (Hungary, MKT)Associate Professor of Marketing (with tenure, 2. Assistant Professor of Marketing (2. Barbara and Gerson Bakar Faculty Fellow (2. Haas School of Business, University of California, Berkeley. Yrjo Koskinen (Finland, FIN)Visiting Faculty, The Wharton School, University of Pennsylvania (2. Assistant Professor of Finance, Boston University School of Management (2. Assistant Professor of Finance, Stockholm School of Economics (1. Mumin Kurtulus (Turkey, POM)Associate Professor (with tenure), Owen Graduate School of Management, Vanderbilt University (2. Assistant Professor of Operations, Owen Graduate School of Management, Vanderbilt University (2. Fatma Lajeri (Tunisia, FIN)Visiting Associate Professor of Finance, Mc. Donough School of Business, Georgetown University (2. Visiting Associate Professor of Finance, Kogod School of Business, American University (2. Assistant Professor of Finance, College of Administrative Sciences and Economics, Koc University (2. Michael A. Lapre (The Netherlands, POM)E. Bronsom Ingram Associate Professor (2. Associate Professor (with tenure, 2. Associate Professor (2. Operations Management, Owen School of Management, Vanderbilt University; Assistant Professor of Operations Management, School of Management, Boston University (1. Mark A. Lehrer (United States, STR)Associate Professor of Strategy and International Business, Sawyer Business School, Suffolk University (2. Associate Professor of Management, College of Business Administration, University of Rhode Island (1. Research Fellow, Social Science Research Center Berlin (1. Otso Massala (Finland, DSC)Associate Professor and Director of Charles H. Diller Center for Entrepreneurial Leadership and Innovation (tenur track), Grove College of Business, Shippensburg University (2. Dmitrii 'Dima' Mikhailovich Leshchinskii (Russia, FIN)Associate Professor of Finance, Menlo College (2. Visiting Assistant Professor of Finance, Leavey School of Business, Santa Clara University (2. Adjunct Professor of Finance, University of Maryland University College (2. Visiting Assistant Professor of Finance, Lally School of Management, Rensselaer Polytechnic Institute (2. Assistant Professor of Finance, HEC Paris (2. Haibo Liu (Singapore, TOM)Assistant Professor, Anderson School of Management, University of California, Riverside (2. Dmitry V. Lukin (Russia, FIN)CIO, Private Investment Fund (2. Director of Corporate Centre, URALSIB Evolution (2. Managing Director, Eastern Ventures Holdings (2. Consultant, Mc. Kinsey and Company (2. Assistant Professor of Finance, The Paul Merage School of Business, University of California- Irvine (1. Simone Marinesi (Italy, TOM)Assistant Professor of Operations Management, The Wharton School, University of Pennsylvania (2. Alfonso Pedraza Martinez (Colombia, TOM)Assistant Professor, Operations and Decision Technologies, Kelley School of Business, Indiana University (2. Pedro Matos (Portugal, FIN)Associate Professor of Finance, Darden School of Business, University of Virginia (2. Research Associate, European Corporate Governance Institute (2. Assistant Professor of Finance, Marshall School of Business, University of Southern California (2. Otilia Obodaru (Romania, OB)Assistant Professor of Management, Jones Graduate School of Business, Rice University (2. Assistant Professor of Organisational Behaviour, Jones Graduate School of Business, Rice University (2. Postdoctoral Fellow, Organizational Behavior Department, INSEAD (2. Postdoctoral Fellow, Visiting Scholar, Organisational Behaviour Department, Harvard Business School (2. Nailya Ordabayeva (Kazakhstan, MKT)Assistant Professor of Marketing, Carroll School of Management, Boston College (2. Assistant Professor of Marketing, Rotterdam School of Management (2. Selcuk Onay (Turkey, DSC)Associate Professor of Management Sciences (2. Assistant Professor of Management Sciences (2. The Laurier School of Business and Economics, University of Waterloo. Vincent Onyemah (Nigeria, MKT)Associate Professor (2. Assistant Professor (2. Marketing, Babson College; Assistant Professor of Marketing, School of Management, Boston University (2. Arzu Ozoguz (Turkey, FIN)Assistant Professor of Finance, Naveen Jindal School of Management, University of Texas (2. Assistant Professor of Finance, Kenan- Flagler School of Business, the University of North Carolina (2.
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